Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts.

Mammalian mitochondria contain several 16.5 kb circular DNAs (mtDNA) encoding electron transport chain proteins. Reactive oxygen species formed as byproducts from oxidative phosphorylation in these organelles can cause oxidative deamination of cytosine and lead to uracil in mtDNA. Upon mtDNA replica...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Stierum, R H, Dianov, G L, Bohr, V A
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1999
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148627/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471741/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.18.3712
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