Segmental genomic replacement in embryonic stem cells by double lox targeting.
We have applied Cre-mediated double lox recombination to embryonic stem (ES) cells to facilitate repeated knock-ins at a target locus, thus helping to assure correct temporal and spatial transgene expression in mice. Using homologous recombination, we inserted a double lox cassette a few nucleo-tide...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148613/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471751/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.18.e21 |
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