Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activatio...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10219080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.10.2086 |
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