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Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice
Hydrocephalus is a common and potentially devastating birth defect affecting the CNS, and its relationship with G protein–coupled receptors (GPCRs) is unknown. We have expressed 2, 4, or 6 copies of a GPCR — the human PAC1 receptor with a 130-kb transgene in the mouse nervous system in a pattern clo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1483148/ https://ncbi.nlm.nih.gov/pubmed/16823490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27597 |
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