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Domains determining agonist selectivity in chimaeric VIP(2) (VPAC(2))/PACAP (PAC(1)) receptors

1. The VPAC(2) and PAC(1) receptors are closely related members of the Group II G protein-coupled receptor family. At the VPAC(2) receptor, VIP is equipotent to PACAP-38 in stimulating cyclic AMP production, whereas at the PAC(1) receptor PACAP-38 is many fold more potent than VIP. In this study, do...

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Autors principals: Lutz, E M, MacKenzie, C J, Johnson, M, West, K, Morrow, J A, Harmar, A J, Mitchell, R
Format: Artigo
Idioma:Inglês
Publicat: 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571712/
https://ncbi.nlm.nih.gov/pubmed/10556928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702872
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