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Acetylation of Estrogen Receptor Alpha by p300 at Lysines 266 and 268 Enhances the DNA Binding and Transactivation Activities of the Receptor
Using a variety of biochemical and cell-based approaches, we show that estrogen receptor a (ERα) is acetylated by the p300 acetylase in a ligand- and steroid receptor coactivator (SRC)-dependent manner. Using mutagenesis and mass spectrometry, we identified two conserved lysine residues in ERα (Lys2...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1483068/ https://ncbi.nlm.nih.gov/pubmed/16497729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2005-0531 |
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