Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides.
Human telomerase is a ribonucleoprotein which uses its internal RNA moiety as a template for telomeric DNA synthesis. This enzyme is up-regulated in most malignant tumors and is therefore considered as a possible cancer target. Here we examined the effects of differently modified oligomers on telome...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1999
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.4.1152 |
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