Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia

BACKGROUND: Protein kinase C (PKC) in the spinal cord appears to mediate chronic injury-induced pain, but not acute nociceptive pain. Muscle insult results in increased release of glutamate spinally, and hyperalgesia that is reversed by spinal blockade of NMDA and non-NMDA glutamate receptors. There...

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Bibliographic Details
Main Authors: Sluka, KA, Audette, KM
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482680/
https://ncbi.nlm.nih.gov/pubmed/16584564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-2-13
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