Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington’s disease

Huntington’s disease (HD) is a fatal, genetic, neurological disorder resulting from a trinucleotide repeat expansion in the gene that encodes for the protein huntingtin. These excessive repeats confer a toxic gain of function on huntingtin, which leads to the degeneration of striatal and cortical ne...

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Detalhes bibliográficos
Main Authors: McBride, Jodi L., Ramaswamy, Shilpa, Gasmi, Mehdi, Bartus, Raymond T., Herzog, Christopher D., Brandon, Eugene P., Zhou, Lili, Pitzer, Mark R., Berry-Kravis, Elizabeth M., Kordower, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482612/
https://ncbi.nlm.nih.gov/pubmed/16751280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508875103
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