A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth

Endogenous angiogenesis inhibitors have shown promise in preclinical trials, but clinical use has been hindered by low half-life in circulation and high production costs. Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination. The vaccination procedur...

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Bibliographische Detailangaben
Hauptverfasser: Holmgren, Lars, Ambrosino, Elena, Birot, Olivier, Tullus, Carl, Veitonmäki, Niina, Levchenko, Tetyana, Carlson, Lena-Maria, Musiani, Piero, Iezzi, Manuela, Curcio, Claudia, Forni, Guido, Cavallo, Federica, Kiessling, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482591/
https://ncbi.nlm.nih.gov/pubmed/16754857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603110103
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