U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway.

Core snRNP proteins bind snRNA through the conserved Sm site, PuA(U)n>/=3GPu. While yeast U1 snRNA has three matches to the Sm consensus, the U1 3'-terminal Sm site was found to be both necessary and sufficient for U1 function. Mutation of this site inhibited pre-mRNA splicing, blocked cell division...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Seipelt, R L, Zheng, B, Asuru, A, Rymond, B C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9862984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.2.587
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