U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway.
Core snRNP proteins bind snRNA through the conserved Sm site, PuA(U)n>/=3GPu. While yeast U1 snRNA has three matches to the Sm consensus, the U1 3'-terminal Sm site was found to be both necessary and sufficient for U1 function. Mutation of this site inhibited pre-mRNA splicing, blocked cell division...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9862984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.2.587 |
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