A re-investigation of the thio effect at the hammerhead cleavage site.

The effect of introducing a phosphorothioate at the hammerhead cleavage site was investigated using a kinetically well-characterized hammerhead. In buffers containing Mg ion, the RP-phosphorothioate isomer cleaved 2000- to 80 000-fold slower than the SPisomer or the unmodified RNA substrate. Additio...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Scott, E C, Uhlenbeck, O C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1999
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148203/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9862968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.2.479
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