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Degradation of the Transcription Factor Gcn4 Requires the Kinase Pho85 and the SCF(CDC4) Ubiquitin–Ligase Complex

Gcn4, a yeast transcriptional activator that promotes the expression of amino acid and purine biosynthesis genes, is rapidly degraded in rich medium. Here we report that SCF(CDC4), a recently characterized protein complex that acts in conjunction with the ubiquitin-conjugating enzyme Cdc34 to degrad...

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Udgivet i:Mol Biol Cell
Principais autores: Meimoun, Ariella, Holtzman, Tsvi, Weissman, Ziva, McBride, Helen J., Stillman, David J., Fink, Gerald R., Kornitzer, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14820/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10712509/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.3.915
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