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The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure.

The 5' and 3' ends of HIV-1 transcripts are identical in sequence. This repeat region (R) folds a stem-loop structure that is termed the poly(A) hairpin because it contains polyadenylation or poly(A) signals: the AAUAAA hexamer motif, the cleavage site and part of the GU-rich downstream element. Obv...

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Publicado no:Nucleic Acids Res
Principais autores: Klasens, B I, Thiesen, M, Virtanen, A, Berkhout, B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148199/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9862964/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.2.446
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