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The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
Regulatory T cells that express the Foxp3 transcription factor play important roles in preventing autoimmune diseases. Although several studies have demonstrated that the lack of the forkhead DNA-binding domain of Foxp3 caused severe autoimmune disease in scurfy mutant mice, the other functional dom...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1480458/ https://ncbi.nlm.nih.gov/pubmed/16769892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600225103 |
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