A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding

The eukaryotic mRNA 3′ poly(A) tail and the 5′ cap cooperate to synergistically enhance translation. This interaction is mediated by the cap-binding protein eIF4E, the poly(A) binding protein (PABP), and eIF4G, a scaffolding protein that bridges between eIF4E and PABP to bring about the circularizat...

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Autores principales: Karim, Muhammad M., Svitkin, Yuri V., Kahvejian, Avak, De Crescenzo, Gregory, Costa-Mattioli, Mauro, Sonenberg, Nahum
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480435/
https://ncbi.nlm.nih.gov/pubmed/16772376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603701103
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