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Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions.
The hairpin ribozyme is a small catalytic RNA that achieves an active configuration by docking of its two helical domains in an antiparallel fashion. Both docking and subsequent cleavage are dependent on the presence of divalent metal ions, such as magnesium, but there is no evidence to date for dir...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1998
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC148042/ https://ncbi.nlm.nih.gov/pubmed/9837982 |
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