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RNA structure adjacent to the attenuation determinant in the 5'-non-coding region influences poliovirus viability.

In attenuated Sabin strains, point mutations within stem-loop V of the 5'-non-coding region (NCR) reduce neurovirulence and cell-specific cap-independent translation. The stem-loop V attenuation determinants lie within the highly structured internal ribosome entry site. Although stem-loop V Sabin mu...

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Udgivet i:Nucleic Acids Res
Principais autores: Stewart, S R, Semler, B L
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148017/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826754/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5318
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