RNA structure adjacent to the attenuation determinant in the 5'-non-coding region influences poliovirus viability.
In attenuated Sabin strains, point mutations within stem-loop V of the 5'-non-coding region (NCR) reduce neurovirulence and cell-specific cap-independent translation. The stem-loop V attenuation determinants lie within the highly structured internal ribosome entry site. Although stem-loop V Sabin mu...
में बचाया:
| में प्रकाशित: | Nucleic Acids Res |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
1998
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5318 |
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