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A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation

Heptameric pores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as portals for entry of the enzymatic moieties of the toxin into the cytosol. In the aqueous lumen of each pore is a “Phe clamp,” a heptad of narrowly apposed Phe residues (Phe-427), that cataly...

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Detalhes bibliográficos
Main Authors: Melnyk, Roman A., Collier, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479862/
https://ncbi.nlm.nih.gov/pubmed/16785422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604000103
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