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A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation
Heptameric pores formed in the endosomal membrane by the protective antigen moiety of anthrax toxin serve as portals for entry of the enzymatic moieties of the toxin into the cytosol. In the aqueous lumen of each pore is a “Phe clamp,” a heptad of narrowly apposed Phe residues (Phe-427), that cataly...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479862/ https://ncbi.nlm.nih.gov/pubmed/16785422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604000103 |
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