Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.

Reactive oxygen species produce different lesions in DNA. Among them, 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major oxidative products implicated in mutagenesis. This lesion is removed from damaged DNA by base excision repair, and genes coding for 8-oxoG-DNA glycosylases have been isolated f...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Prieto Alamo, M J, Jurado, J, Francastel, E, Laval, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147981/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9801319/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.22.5199
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