The BARD1 Cys557Ser Variant and Breast Cancer Risk in Iceland

BACKGROUND: Most, if not all, of the cellular functions of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1. Some breast-cancer-associated BRCA1 missense mutations disrupt the function of the BRCA1/BARD1 complex. It is therefore pertinent...

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Main Authors: Stacey, Simon N, Sulem, Patrick, Johannsson, Oskar T, Helgason, Agnar, Gudmundsson, Julius, Kostic, Jelena P, Kristjansson, Kristleifur, Jonsdottir, Thora, Sigurdsson, Helgi, Hrafnkelsson, Jon, Johannsson, Jakob, Sveinsson, Thorarinn, Myrdal, Gardar, Grimsson, Hlynur Niels, Bergthorsson, Jon T, Amundadottir, Laufey T, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari
格式: Artigo
語言:Inglês
出版: Public Library of Science 2006
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479388/
https://ncbi.nlm.nih.gov/pubmed/16768547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030217
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