Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin

We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (K(d)) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the trad...

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Bibliographic Details
Main Authors: Kakita, Mai, Takahashi, Tsuyoshi, Komiya, Takako, Iba, Yoshitaka, Tsuji, Takao, Kurosawa, Yoshikazu, Takahashi, Motohide
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479265/
https://ncbi.nlm.nih.gov/pubmed/16714603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01731-05
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