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Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin
We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (K(d)) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the trad...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479265/ https://ncbi.nlm.nih.gov/pubmed/16714603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01731-05 |
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