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A formula for thermal stability (Tm) prediction of PNA/DNA duplexes.

An empirical formula for thermal stability (T m) prediction of PNA/DNA duplexes has been derived. The model is based on the T m as calculated for the corresponding DNA/DNA duplex employing a nearest neighbour approach, by including terms for the pyrimidine content and length of the PNA to take into...

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Bibliografische gegevens
Hoofdauteurs: Giesen, U, Kleider, W, Berding, C, Geiger, A, Orum, H, Nielsen, P E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1998
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC147916/
https://ncbi.nlm.nih.gov/pubmed/9776766
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