Helix 2 of the paired domain plays a key role in the regulation of DNA-binding by the Pax-3 homeodomain.
Pax3 contains two structurally independent DNA-binding domains, a paired domain (PD) and a homeodomain (HD). Biochemical and mutagenesis studies have shown that both domains are functionally interdependent. In particular, it has been shown that the PD can regulate the DNA-binding specificity and dim...
Guardat en:
| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147906/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9753723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.20.4574 |
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