Helix 2 of the paired domain plays a key role in the regulation of DNA-binding by the Pax-3 homeodomain.

Pax3 contains two structurally independent DNA-binding domains, a paired domain (PD) and a homeodomain (HD). Biochemical and mutagenesis studies have shown that both domains are functionally interdependent. In particular, it has been shown that the PD can regulate the DNA-binding specificity and dim...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Fortin, A S, Underhill, D A, Gros, P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147906/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9753723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.20.4574
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