Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively.

Nuclear (UNG2) and mitochondrial (UNG1) forms of human uracil-DNA glycosylase are both encoded by the UNG gene but have different N-terminal sequences. We have expressed fusion constructs of truncated or site-mutated UNG cDNAs and green fluorescent protein cDNA and studied subcellular sorting. The u...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Otterlei, M, Haug, T, Nagelhus, T A, Slupphaug, G, Lindmo, T, Krokan, H E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147895/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9753728/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.20.4611
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