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Anomeric inversion (from beta to alpha) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA.

Here we report that the poor binding of methylphosphonate oligodeoxynucleosides (MP-ODNs) to their nucleic acid targets can be improved by additional inversion of the anomeric configuration (from beta to alpha) in the sugar moieties to give a new class of analogs, MP alpha-oligonucleosides. MP alpha...

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Udgivet i:Nucleic Acids Res
Principais autores: Debart, F, Meyer, A, Vasseur, J J, Rayner, B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147882/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9753720/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.20.4551
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