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The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.

The class II transactivator CIITA is required for transcriptional activation of the major histocompatibility complex (MHC) class II genes. Aside from an N-terminal acidic transcriptional activation domain, little is known about how this factor functions. Extensive mutagenesis of CIITA was undertaken...

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Udgivet i:Nucleic Acids Res
Principais autores: Brown, J A, Rogers, E M, Boss, J M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147839/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9722631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.18.4128
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