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HIC1 attenuates Wnt signaling by recruitment of TCF-4 and β-catenin to the nuclear bodies
The hypermethylated in cancer 1 (HIC1) gene is epigenetically inactivated in cancer, and in addition, the haploinsufficiency of HIC1 is linked to the development of human Miller–Dieker syndrome. HIC1 encodes a zinc-finger transcription factor that acts as a transcriptional repressor. Additionally, t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1478201/ https://ncbi.nlm.nih.gov/pubmed/16724116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601147 |
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