Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state

ClyA is a pore-forming toxin from virulent Escherichia coli and Salmonella enterica strains. Here, we show that the intrinsic hemolytic activity of ClyA is independent of its redox state, and that the assembly of both reduced and oxidized ClyA to the ring-shaped oligomer is triggered by contact with...

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Autori principali: Eifler, Nora, Vetsch, Michael, Gregorini, Marco, Ringler, Philippe, Chami, Mohamed, Philippsen, Ansgar, Fritz, Andrea, Müller, Shirley A, Glockshuber, Rudi, Engel, Andreas, Grauschopf, Ulla
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1478193/
https://ncbi.nlm.nih.gov/pubmed/16688219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601130
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