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Inhibition of IFN-γ transcription by site-specific methylation during T helper cell development
Polarization of naïve CD4 T cells into T helper type 2 (T(H)2) cells is characterized by expression of IL-4 and silencing of IFN-γ. Here we show that during T(H)2 polarization, the DNA methyltransferase Dnmt3a is recruited to the IFN-γ promoter and correspondingly the promoter undergoes progressive...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1478170/ https://ncbi.nlm.nih.gov/pubmed/16724115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601148 |
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