Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines.

The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the phosphoramidites and incorporated into oligodeoxynucleotides. Spectroscopic melting experiments against complementary RNA showed increases of 3...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Balow, G, Mohan, V, Lesnik, E A, Johnston, J F, Monia, B P, Acevedo, O L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9649618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.14.3350
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