Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines.

The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the phosphoramidites and incorporated into oligodeoxynucleotides. Spectroscopic melting experiments against complementary RNA showed increases...

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Bibliographic Details
Main Authors: Balow, G, Mohan, V, Lesnik, E A, Johnston, J F, Monia, B P, Acevedo, O L
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC147716/
https://ncbi.nlm.nih.gov/pubmed/9649618
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