Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions

The genes for the α and β chains of a highly reactive anti-MART-1 T-cell receptor were isolated from T-lymphocytes that mediated in vivo regression of tumor in a patient with metastatic melanoma. These genes were cloned and inserted into MSCV-based retroviral vectors. After transduction, greater tha...

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Main Authors: HUGHES, MARYBETH S., YU, YIK Y.L., DUDLEY, MARK E., ZHENG, ZHILI, ROBBINS, PAUL F., LI, YONG, WUNDERLICH, JOHN, HAWLEY, ROBERT G., MOAYERI, MORVARID, ROSENBERG, STEVEN A., MORGAN, RICHARD A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1476695/
https://ncbi.nlm.nih.gov/pubmed/15871677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2005.16.457
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