The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity.
Human DNA topoisomerase I not only has DNA relaxing activity, but also splicing factors phosphorylating activity. Topo I shows strong preference for ATP as the phosphate donor. We used photoaffinity labeling with the ATP analogue [alpha-32P] 8-azidoadenosine-5'-triphosphate combined with limited pro...
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| 發表在: | Nucleic Acids Res |
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| Principais autores: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
1998
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2963 |
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