The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity.

Human DNA topoisomerase I not only has DNA relaxing activity, but also splicing factors phosphorylating activity. Topo I shows strong preference for ATP as the phosphate donor. We used photoaffinity labeling with the ATP analogue [alpha-32P] 8-azidoadenosine-5'-triphosphate combined with limited pro...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Rossi, F, Labourier, E, Gallouzi, I E, Derancourt, J, Allemand, E, Divita, G, Tazi, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2963
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