Novel internucleotide 3'-NH-P(CH3)(O)-O-5' linkage. Oligo(deoxyribonucleoside methanephosphonamidates); synthesis, structure and hybridization properties.

Diastereomeric dithymidine methanephosphonamidates (TnpmT) were synthesized by reaction of 3'-amino-3'-deoxythymidine with 3'- O -acetylthymidin-5-yl-methanephosphonochloridate. Separated dinucleotide TnpmT(fast) and TnpmT(slow) diastereomers were used as building blocks to prepare chimeric dodecath...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Nawrot, B, Boczkowska, M, Wójcik, M, Sochacki, M, Kazmierski, S, Stec, W J
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1998
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9592150/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.11.2650
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