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2',5'-linked oligo-3'-deoxyribonucleoside phosphorothioate chimeras: thermal stability and antisense inhibition of gene expression.

2',5'-Linked oligo-3'-deoxyribonucleotides bind selectively to complementary RNA but not to DNA. These oligonucleotides (ODNs) do not recognize double-stranded DNA by Hoogsteen triplex formation and the complexes formed by these ODNs with RNA are not substrates for Escherichia coli RNase H. Substitu...

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Udgivet i:Nucleic Acids Res
Principais autores: Bhan, P, Bhan, A, Hong, M, Hartwell, J G, Saunders, J M, Hoke, G D
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9241246/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.16.3310
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