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Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint

The protein kinase Chk1 enforces the DNA damage checkpoint. This checkpoint delays mitosis until damaged DNA is repaired. Chk1 regulates the activity and localization of Cdc25, the tyrosine phosphatase that activates the cdk Cdc2. Here we report that Mik1, a tyrosine kinase that inhibits Cdc2, is po...

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Udgivet i:Mol Biol Cell
Principais autores: Baber-Furnari, Beth A., Rhind, Nick, Boddy, Michael N., Shanahan, Paul, Lopez-Girona, Antonia, Russell, Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14752/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.1.1
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