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Reduced susceptibility to ischemic brain injury and N-methyl-d-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice

Cyclooxygenase-2 (COX-2), a prostanoid-synthesizing enzyme that contributes to the toxicity associated with inflammation, has recently emerged as a promising therapeutic target for several illnesses, ranging from osteoarthritis to Alzheimer's disease. Although COX-2 has also been linked to ischemic...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Iadecola, Costantino, Niwa, Kiyoshi, Nogawa, Shigeru, Zhao, Xueren, Nagayama, Masao, Araki, Eiichi, Morham, Scott, Ross, M. Elizabeth
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14748/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.3.1294
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