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The Function and Regulation of Budding Yeast Swe1 in Response to Interrupted DNA Synthesis

Periodically regulated cyclin-dependent kinase (Cdk) is required for DNA synthesis and mitosis. Hydroxyurea (HU) inhibits DNA synthesis by depleting dNTPs, the basic unit for DNA synthesis. HU treatment triggers the S-phase checkpoint, which arrests cells at S-phase, inhibits late origin firing and...

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Bibliografske podrobnosti
Main Authors: Liu, Hong, Wang, Yanchang
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474790/
https://ncbi.nlm.nih.gov/pubmed/16571676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-11-1093
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