Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice

Rpe65 knockout mice (Rpe65(−/−)) are unable to synthesize the visual pigment chromophore 11-cis retinal; however, if these animals are reared in complete darkness, the rod photoreceptors accumulate a small amount of 9-cis retinal and its corresponding visual pigment isorhodopsin. Suction-electrode r...

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Bibliographic Details
Main Authors: Fan, Jie, Woodruff, Michael L, Cilluffo, Marianne C, Crouch, Rosalie K, Fain, Gordon L
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Cell Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474752/
https://ncbi.nlm.nih.gov/pubmed/15994181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.091942
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