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Metabolic aspects of pyrolysis mutagens in food.

The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readily react with DNA. The adducts between the metabolites of Trp-...

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Detaylı Bibliyografya
Asıl Yazarlar: Sato, S, Negishi, C, Umemoto, A, Sugimura, T
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1986
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474417/
https://ncbi.nlm.nih.gov/pubmed/3757943
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