Parallel thermodynamic analysis of duplexes on oligodeoxyribonucleotide microchips.

A microchip method has been developed for massive and parallel thermodynamic analyses of DNA duplexes. Fluorescently labeled oligonucleotides were hybridized with oligonucleotides immobilized in the 100 x 100 x 20 mum gel pads of the microchips. The equilibrium melting curves for all microchip duple...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Fotin, A V, Drobyshev, A L, Proudnikov, D Y, Perov, A N, Mirzabekov, A D
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9490800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.6.1515
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