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Depletion of SMN by RNA interference in HeLa cells induces defects in Cajal body formation
Neuronal degeneration in spinal muscular atrophy (SMA) is caused by reduced expression of the survival of motor neuron (SMN) protein. The SMN protein is ubiquitously expressed and is present both in the cytoplasm and in the nucleus where it localizes in Cajal bodies. The SMN complex plays an essenti...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1474063/ https://ncbi.nlm.nih.gov/pubmed/16738131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl374 |
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