Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca(2+)-permeable nonselective cation channel

Defects in polycystin-2, a ubiquitous transmembrane glycoprotein of unknown function, is a major cause of autosomal dominant polycystic kidney disease (ADPKD), whose manifestation entails the development of fluid-filled cysts in target organs. Here, we demonstrate that polycystin-2 is present in ter...

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Autores principales: González-Perrett, Silvia, Kim, Keetae, Ibarra, Cristina, Damiano, Alicia E., Zotta, Elsa, Batelli, Marisa, Harris, Peter C., Reisin, Ignacio L., Arnaout, M. Amin, Cantiello, Horacio F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC14729/
https://ncbi.nlm.nih.gov/pubmed/11252306
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