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Erythroblast Transformation by the Friend Spleen Focus-Forming Virus Is Associated with a Block in Erythropoietin-Induced STAT1 Phosphorylation and DNA Binding and Correlates with High Expression of the Hematopoietic Phosphatase SHP-1

Infection of mice with Friend spleen focus-forming virus (SFFV) results in a multistage erythroleukemia. In the first stage, the SFFV envelope glycoprotein interacts with the erythropoietin receptor and a short form of the receptor tyrosine kinase sf-Stk, resulting in constitutive activation of sign...

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Detalhes bibliográficos
Main Authors: Nishigaki, Kazuo, Hanson, Charlotte, Ohashi, Takashi, Spadaccini, Angelo, Ruscetti, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472600/
https://ncbi.nlm.nih.gov/pubmed/16731906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02651-05
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