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Mutations in Influenza Virus M1 CCHH, the Putative Zinc Finger Motif, Cause Attenuation in Mice and Protect Mice against Lethal Influenza Virus Infection

Mutations in CCHH, the putative zinc finger motif, apparently do not play an important role in virus replication in MDCK cells in culture (E. K.-W. Hui, K. Ralston, A. K. Judd, and D. P. Nayak, J. Gen. Virol. 84:3105-3113, 2003). In this report, however, we demonstrate that the CCHH motif plays a cr...

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Bibliografske podrobnosti
Main Authors: Hui, Eric Ka-Wai, Smee, Donald F., Wong, Min-Hui, Nayak, Debi P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472591/
https://ncbi.nlm.nih.gov/pubmed/16731908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02729-05
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