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Mutations in Influenza Virus M1 CCHH, the Putative Zinc Finger Motif, Cause Attenuation in Mice and Protect Mice against Lethal Influenza Virus Infection

Mutations in CCHH, the putative zinc finger motif, apparently do not play an important role in virus replication in MDCK cells in culture (E. K.-W. Hui, K. Ralston, A. K. Judd, and D. P. Nayak, J. Gen. Virol. 84:3105-3113, 2003). In this report, however, we demonstrate that the CCHH motif plays a cr...

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Detalhes bibliográficos
Main Authors: Hui, Eric Ka-Wai, Smee, Donald F., Wong, Min-Hui, Nayak, Debi P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472591/
https://ncbi.nlm.nih.gov/pubmed/16731908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02729-05
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