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Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator

Purkinje neurons (PNs), the central cells in cerebellar circuitry and function, constitute a vulnerable population in many human genetic, malignant, hypoxic, and toxic diseases. In the nervous (nr) mutant mouse, the majority of PNs die in the fourth to fifth postnatal weeks, but the responsible mole...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Jianxue, Ma, Yinghua, Teng, Yang D., Zheng, Kangni, Vartanian, Timothy K., Snyder, Evan Y., Sidman, Richard L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472533/
https://ncbi.nlm.nih.gov/pubmed/16682647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602440103
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